2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-111084
    UK 52831
    		Inhibitor
    UK 52831 is a long acting dihydropyridine calcium channel antagonist. UK 52831 can be used for cardiovascular disease (such as hypertension and myocardial ischemia) and anti-inflammatory research.
    UK 52831
  • HY-14744C
    Levamlodipine hydrobromide
    		Inhibitor
    Levamlodipine ((S)-Amlodipine; Levoamlodipin) hydrobromide is an orally active L-type calcium channel blocker and MMP-9 modulator with high permeability and retention properties. Levamlodipine hydrobromide significantly enhances plaque stability and improves lipid profiles by reducing blood pressure, decreasing systolic blood pressure variability, and inhibiting MMP-9 expression in atherosclerotic plaques. Levamlodipine hydrobromide not only alleviates cardiac and aortic hypertrophy and prevents renal atrophy, but also produces synergistic effects in blood pressure reduction and organ protection when combined with bisoprolol (HY-129029). Levamlodipine hydrobromide exerts no significant inhibitory effect on abdominal aortic intimal hyperplasia. When excessively accumulated in the epidermis, Levamlodipine hydrobromide may induce changes in keratin structure, impair the skin barrier and trigger inflammation; long-term use further exacerbates skin irritation caused by local administration. Levamlodipine hydrobromide can be used in research related to hypertension and atherosclerosis.
    Levamlodipine hydrobromide
  • HY-135478
    LY393615
    		Inhibitor
    LY393615 (NCC1048) is a novel neuronal Ca2+ (calcium channel) and Na + channel (sodium channel) blocker with IC50s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research.
    LY393615
  • HY-B0166C
    L-Ascorbic acid calcium dihydrate
    		Inhibitor
    L-Ascorbic acid (calcium dihydrate) (L-Ascorbate (calcium dihydrate); Vitamin C (calcium dihydrate)) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    L-Ascorbic acid calcium dihydrate
  • HY-P2061
    Leualacin
    		Inhibitor
    Leualacin, a calcium channel blocker, can be isolated from the fungus Hapsidospora irregularis.
    Leualacin
  • HY-U00026
    Semotiadil recemate fumarate
    Semotiadil recemate fumarate is the recemate of Semotiadil fumarate. Semotiadil fumarate is a novel vasoselective Ca2+ channel antagonist.
    Semotiadil recemate fumarate
  • HY-101707
    UK51656
    		Antagonist
    UK51656 is a calcium antagonist with IC50 of 4 nM.
    UK51656
  • HY-120816
    WU-07047
    WU-07047, a simplified analog of YM-254890 (HY-111557), is a selective Gαq/11 inhibitor. WU-07047 can inhibit nucleotide exchange.
    WU-07047
  • HY-B0317AS1
    Amlodipine-d9 maleate
    		Antagonist
    Amlodipine-d9 maleate is deuterated labeled Amlodipine maleate (HY-B0317A). Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.
    Amlodipine-d<sub>9</sub> maleate
  • HY-17402S3
    Nisoldipine-d3
    		Inhibitor
    Nisoldipine-d3 is deuterated labeled Nisoldipine (HY-17402). Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM.
    Nisoldipine-d<sub>3</sub>
  • HY-A0016S
    Dronedarone-d6 hydrochloride
    		Inhibitor
    Dronedarone-d6 (hydrochloride) is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4.
    Dronedarone-d<sub>6</sub> hydrochloride
  • HY-182351
    ONO-2921
    		Inhibitor
    ONO-2921 is an orally active and selective N-type calcium channel blocker. ONO-2921 functionally blocks N-type calcium channels. ONO-2921 reduces paw withdrawal responses during persistent nociception and hyperalgesia to heat in neuropathic pain models. ONO-2921 can be used for research on neuropathic pain and nociceptive pain.
    ONO-2921
  • HY-147708
    T-Type calcium channel inhibitor 2
    		Inhibitor
    T-Type calcium channel inhibitor 2 (compound 6g) is a potent T-type calcium channel inhibitor with IC50s of 31.0, 83.1, 69.3 µM for Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) (α1H), respectively. T-Type calcium channel inhibitor 2 shows cytotoxicity for A549, HCT-116 cells with IC50s of 5.0, 6.4 µM, respectively.
    T-Type calcium channel inhibitor 2
  • HY-P6008
    Myoregulin
    Myoregulin (MLN peptide) is a member of the regulin family. Myoregulin regulates muscle performance by modulating intracellular calcium handling. Myoregulin interactes directly with sarcoplasmic reticulum Ca2+-ATPase (SERCA) and impedinf Ca2+ uptake into the sarcoplasmic reticulum.
    Myoregulin
  • HY-17404S
    Cilnidipine-d7
    		Inhibitor
    Cilnidipine-d7 is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel. Antihypertensive effects.
    Cilnidipine-d<sub>7</sub>
  • HY-164648
    Flosatidil
    		Antagonist
    Flosatidil (SL 85.1016) is an orally active Calcium Channel antagonist. Flosatidil has antianginal and antihypertensive properties.
    Flosatidil
  • HY-167925S
    2'-O-Methyl Uridine-d3
    2'-O-Methyl Uridine-d3 is the deuterium labeled Rec 15/2615 (HY-167925). Rec 15/2615 is a potent α(1)-adrenergic agonist that stimulates small cholangiocyte proliferation through the activation of calcium-dependent signaling pathways.
    2'-O-Methyl Uridine-d<sub>3</sub>
  • HY-121746
    GW7845
    		Inhibitor
    GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARγ agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC50 of 3 μM by using Ba2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells.
    GW7845
  • HY-B0768
    Lomerizine
    		Antagonist
    Lomerizine is an antagonist of L- and T-type voltagegated calcium channels.
    Lomerizine
  • HY-173618
    LQFM020
    		Inhibitor
    LQFM020 is an orally active pyrazole derivative. LQFM020 inhibits Ca+ and activates K+ and NO/cGMP channels to inhibit vasoconstriction. LQFM020 has anti-inflammatory and anti-analgesic activities.
    LQFM020
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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